Trade Magazine/Scholarly Articles

"Treatment of autosomal dominant polycystic kidney disease (ADPKD)"

This scholarly article explores the genetic and molecular basis for PKD and reviews the clinical manifestations in children with ADPKD.  Now that more is becoming known about the molecular basis, more targets for therapy are being discovered.  These developments also help children with screening for PKD and for identification of high-risk individuals.  This article would be helpful for anyone looking for a detailed description of the research being conducted in the genetics field.  It might also prove useful for those with children who suffer from ADPKD because this new research has the potential to greatly change their lives.

Chapman, Arlene and Dana Rizk.  “Treatment of autosomal dominant polycystic kidney disease (ADPKD): the new horizon for children with ADPKD.”  Pediatric Nephrology.  Vol. 23, No. 7.  2008. 1029-1036.  Academic Search Complete.  EBSCO.  3 June 2008.  

"Bilateral laparoscopic nephrectomy for significantly enlarged polycystic kidneys"

This scholarly journal article is aimed at reducing the size of massively enlarged polycystic kidneys by a technique known as bilateral laparoscopic nephrectomy (BLN).  The procedure would be used on symptomatic patients with ADPKD, which would include candidates for transplantation.   This article follows a specific study done using BLNs.  It would be a good source for those who are interested in research on reducing the size of polycystic kidneys.  The massive size of infected kidneys is sometimes a problem for PKD sufferers and this research would help combat the massive size of the kidneys.

Desai, Premal J., et al.  “Bilateral laparoscopic nephrectomy for significantly enlarged polycystic kidneys: a technique to optimize outcome in the largest of specimens.”  BJU International.  Vol. 101, No. 8.  2008.  1019-1023.  Academic Search Complete.  EBSCO.  3 June 2008.

"Polycystic kidney disease and the renal cilium"

In this article Deane and Ricardo report on their studies of PKD and a possible cause of PKD that results from a defect of the renal cilium.  The article goes into details about the link between cilia and the different forms of PKD.  The article sights a defective renal cilium as the cause of the cysts that form in the kidneys.  This is still just a recent discovery in the field of PKD so the article provides a good resource for the new information.  Their research comes from the Monash Immunology and Stem Cell Laboratories in Monach University, Australia.

Deane, James A., and Sharon D. Ricardo.  “Polycystic kidney disease and the renal cilium”  Nephrology.  Vol. 12, No. 6.  2007.  559-564. Academic Search Complete.  EBSCO.  16 April 2008.